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Investigators

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CHAVI Director

Barton Haynes
Duke University

CHAVI Chief Operating Officer

Thomas Denny
Duke University 

CHAVI Scientific Leadership Group

Myron Cohen
University of North Carolina at Chapel Hill

David Goldstein
Duke University

Barton Haynes
Duke University

Bette Korber
Los Alamos National Laboratory

Norman Letvin
Beth Israel Deaconess Medical Center

Andrew McMichael
Oxford University 

George Shaw
University of Alabama at Birmingham

Joseph Sodroski
Dana-Farber Cancer Institute

CHAVI Discovery Team Leaders

Persephone Borrow
Innate Immunity Discovery Team

David Goldstein
Host Genetics and Genomics Discovery Team

Beatrice Hahn
Viral Biology Discovery Team

Stephen Harrison
Structural Biology Discovery Team

Barton Haynes
Vaccine Design Discovery Team

Norman Letvin
Adjuvant Development Discovery Team and Non-Human Primate Correlates of Immunity of Live Attenuated SIV Discovery Team

Andrew McMichael
Innate Immunity Discovery Team and T cell Immunology Discovery Team

Robin Shattock
Mucosal Immunity Discovery Team

George Shaw
B cell Immunology Discovery Team

Joseph Sodroski
Structural Biology Discovery Team

 
CHAVI Core Leaders
 

David Goldstein
Host and Viral Genetics Core

Myron Cohen
Clinical Sites and Repository Core

Norman Letvin
Vector Development Core and Core G: Non-Human Primate Core

Stephen Harrison
Structural Biology Core

Raphael Dolin
Clinical Trials Core

Kent Weinhold
Immune Monitoring Core

Bette Korber
Computational Biology Core

James Robinson
Monoclonal Antibody Core

Beatrice Hahn
Viral Sequencing Core

Munir Alam
Proteomics Core

 
 CHAVI Investigators (listed in alphabetical order)
 
University of KwaZulu-Natal
Clinical Sites Core B: Investigator
Galit Alter
Massachusetts General Hospital
Innate Immunity Discovery Team: Investigator
Marcus Altfeld
Harvard University
Innate Immunity Discovery Team: Investigator
Jacques Banchereau
Baylor University
RO1-Aim 2: Investigator
Duke University
Clinical Sites Core B: Crump: Investigator
New York University
Innate Immunity Discovery Team: Investigator
Marina Cella
Washington University
Innate Immunology Discovery Team: Investigator
Galvin Churchyard
Aurum Institute for Health Research
Clinical Sites Core B: Investigato
Amy Corneli
Family Health International, Inc.
Clinical Sites Core B: Investigato
Kilimanjaro Christian Medical Centre
Clinical Sites Core B: Site Co-Leader
Philippa Easterbrook
King’s College
Clinical Sites Core B: Investigator
Joseph Eron
University of North Carolina at Chapel Hill
Clinical Sites Core B: Investigator
Sarah Fidler
Imperial College
Clinical Sites Core B and Viral Sequencing Core: Investigator
University of North Carolina at Chapel Hill
Clinical Sites Core B: UNC Repository, Investigator
Duke University
Clinical Sites Core B: Duke Repository, Investigator
 Don Forthal
University of California at Irvine
Mucosal Immunity Discovery Team: Investigator
Feng Gao
Duke University
Host and Viral Genetics Core: Investigator
Cynthia Gay
University of North Carolina at Chapel Hill
Clinical Sites Core B: Investigator
 Paul Goepfert
University of Alabama at Birmingham
Clinical Sites Core B: Investigator
Nilu Goonetilleke
Oxford University
Investigator
National Institute for Communicable Diseases
Clinical Sites Core Band Immune Monitoring Core F: Investigator
Uganda Virus Research Institute
Clinical Sites Core B: Investigator
Duke University
Clinical Sites Core B: Investigator
Irving Hoffman
University of North Carolina at Chapel Hill
Clinical Sites Core B: Investigator
Thomas Hope
Northwestern University
Mucosal Immunity Discovery Team: Investigator
Laura Jones
Cornell University
Computational Biology Core: Investigator
Pontiano Kaleebu
Uganda Virus Research Institute
Clinical Sites Core B: Investigator
Saidi Kapiga
Harvard School of Public Health
Clinical Sites Core B: Investigator
John Kappes
University of Alabama-Birmingham
Mucosal Immunity Discovery Team: Investigator
David Katz
Duke University
Mucosal Immunity Discovery Team: Repository, Investigator
Johnstone Kumwenda
University of Malawi College of Medicine
Clinical Sites Core B: Investigator
Catherine MacPhail
University of Witwatersrand, Reproductive Health and HIV Research Unit
Clinical Sites Core B: Investigator
David Margolis
University of North Carolina at Chapel Hill
Clinical Sites Core B: Investigator
Marty Markowitz
Aaron Diamond Research Center
Innate and B cell Discovery Teams: Investigator
Francis Martinson
Lilongwe Central Hospital
Clinical Sites Core B: Investigator
Steve Meshnick
University of North Carolina at Chapel Hill
CHAVI 009: Maternal to Child Transmission: Investigator
David Montefiori
Duke University
Immune Monitoring Core F: Investigator
Duke University
CHAVI Chief Medical Officer
CHAVI B cell Immune Monitoring Core
Lynn Morris
National Institute for Communicable Diseases
Immune Monitoring Core F: Investigator
Mark Muldoon
University of Manchester
Clinical Sites Core B and Computational Biology Core: Investigator
Victor Mwapasa
Malawi College of Medicine
CHAVI 009: Maternal to Child Transmission: Investigator
University of California, Blood Systems Research Institute
RO1-Aim 2: Investigator
JoAnn Passmore
University of Cape Town 
Mucosal Discovery Team: Investigator
Alan Perelson
Los Alamos National Laboratory
Computational Biology Core: Math Exp, Investigator
Sallie Permar
Beth Israel Deaconess Hospital and Medical Center
CHAVI 009: Maternal to Child Transmission: Investigator
Audrey Pettifor
University of North Carolina at Chapel Hill
Clinical Sites Core B: Investigator
Helen Rees
University of Witwatersrand, Reproductive Health & HIV Research Unit
Clinical Sites Core B: Investigator
Sarah Rowland-Jones
John Radcliffe Hospital
B cell Discovery Team: Investigator
Noel Sam
Kilimanjaro Christian Medical Centre
Clinical Sites Core B: Investigator
Marcella Sarzotti-Kelsoe
Duke University
Clinical Sites Core B: Quality Assurance, Investigator
Statistical Center for HIV/AIDS Research & Prevention (SCHARP)
CHAVI Relational Database: Investigator
Nicholas Shaheen
University of North Carolina at Chapel Hill
Clinical Sites Core B: Investigator
John Shao
Kilimanjaro Christian Medical Center
Clinical Sites Core B: Investigator
Kevin Shianna
Duke University
Host Genetics Core A and Discovery Team: Investigator
Phillip Smith   
University of Alabama-Birmingham
Mucosal Team: Investigator
Wendy Stevens
 
University of Witwatersrand, Reproductive Health & HIV Research Unit
Clinical Sites Core B: Quality Control, Investigator
University of North Carolina at Chapel Hill
Host and Viral Genetics Core: Investigator
University of Malawi College of Medicine
Clinical Sites Core B: Investigator
Amalio Telenti 
Swiss Centre Hospitalier Universitaire Vaudois 
RO1 Aim 4: Investigator
 
Duke University
Mucosal Immunity Team and Immune Monitoring Core F: Investigator
Kent Weinhold
Duke University
RO1-Aim 2: Investigator
Carolyn Williamson
University of Cape Town
Host Genetics Core A and Viral Sequencing Core: Investigator
Xinzhen Yang
Beth Israel Deaconess Hospital Medical Center
Neutralizing Antibodies Study
 
CHAVI Early Career Investigators
 
NAME INSTITUTION PROJECT TITLE
MENTORS
 
COHORT 1 (2009-2011)
    
David Kaufman, MD, PhD Beth Israel Deaconess Medical Center Strategies to Expand the Breadth of Vaccine-Elicited HIV-specific CD8+ T-Lymphocyte Responses Dan Barouch and Raphael Dolin
Shelby O'Connor, PhD University of Wisconsin Defining the need for epitope-specific CD8 T-cells in a successful HIV vaccine David O'Connor and Esper Kallas
Sallie Permar, MD, PhD Children's Hospital Boston Vaccine-induction of HIV/SIV-specific, protective immune responses in breast milk Norman Letvin and Coleen Cunningham
Keith Reeves, PhD New England Primate Research Center Role of natural killer cells in vaccine-elicited control of HIV/SIV infections Paul Johnson and Marcus Altfeld
Lili Yang, PhD California Institute of Technology Evaluation of a Dendritic Cell-Directed SIV Vaccine in Nonhuman Primates Gary Nabel and Juliana McElrath

COHORT 2 (2010-2012)

    
Mohammed Asmal, MD, PhD Beth Israel Deaconess Medical Center Novel Transmitted Env SHIV for Investigating Mucosal Transmission in Rhesus Raphael Dolin, Joseph Sodroski, and Norman Letvin
Katherine Bar, MD University of Alabama-Birmingham Neutralization sensitivity of SIVsmE660 transmitted/founder viruses Norman Letvin and George Shaw
Anne-Sophie Dugast, PhD Massachusetts General Hospital Impact of non-neutralizing antibodies on SHIV challenge Dan Barouch and Galit Alter
James Kobie, PhD University of Rochester Understanding the B cell response to SIV/HIV in non-human primates Michael Keefer, Nancy Haigwood, and Ignacio Sanz

COHORT 3 (2011-2012)

    
Carolina Herrera, PhD St. George's, University of London Use of tissue explants to evaluate mucosal immune response in NHPs and humans Jerome Kim and Ronald Veazey
Afam Okoye, PhD Oregon Health & Science University  Role of NK cells in Antibody Mediated Protection Following SHIV Challenge Otto Yang and Louis Picker
Lu-Ann Pozzi, PhD New England Primate Research Center An in vivo cytolytic CD8+ T lymphocyte assay for evaluating AIDS vaccine efficacy Xu Yu and Amitinder Kaur
Keith Reeves, PhD New England Primate Research Center Role of natural killer cells in control of HIV/SIV infections Galit Alter and Paul Johnson
Shaunna (Xiaoying) Shen, DVM, PhD  Duke University Medical Center  Antibody Measurements Indicative of Protective Antibodies for HIV-1 Anthony Moody and Georgia Tomaras
Wendy Yeh, MD Beth Israel Deaconess Medical Center HIV/SIV Mucosal Pathogenesis in the Male Genital tract Raphael Dolin and Norman Letvin