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Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery

Based on the success of the CHAVI, two new Centers for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) have been established at Duke University and the Scripps Institute to continue to meet the goal of developing an HIV vaccine.


Major Discoveries of the CHAVI

The major discoveries of the CHAVI were as follows: 1) the delineation of HIV-1 transmitted/founder viruses that are responsible for the transmission of HIV/AIDS; 2) the discovery of host tolerance mechanisms that limit the induction of broad neutralizing antibodies in HIV-1 infection; 3) the fine mapping and delineation of the immunological events that transpire during the earliest days of HIV-1 infection; 4) the discovery of new genes and gene mutations/duplications that contribute to HIV-1 control and progression; 5) the design of mosaic T cell and B cell Env vaccine candidates to overcome HIV diversity; 6) the discovery of the immune correlates of risk of infection in the RV144 trial;7) the isolation of rare broad neutralizing HIV antibodies and their ancestor antibodies; and 8) the development of a new strategy for vaccine development called B Cell Lineage Immunogen Design.

Publications

Tomaras GD, Ferrari G, Shen X, Alam SM, Liao HX, Pollara J, Bonsignori M, Moody MA, Fong Y, Chen X, Poling B, Nicholson CO, Zhang R, Lu X, Parks R, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Gilbert PB, Kim JH, Michael NL, Montefiori DC, Haynes BF. Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. Proc Natl Acad Sci U S A. 2013 May 9. [Epub ahead of print] Abstract

Liu P, Yates NL, Shen X, Bonsignori M, Moody MA, Liao HX, Fong Y, Alam SM, Overman RG, Denny T, Ferrari G, Ochsenbauer C, Kappes JC, Polonis V, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Montefiori DC, Gilbert P, Michael NL, Kim JH, Haynes BF, Tomaras GD. Infectious Virion Capture by HIV-1 gp120 Specific IgG from RV144 Vaccinees. J Virol. 2013 May 8. [Epub ahead of print] Abstract

Video Presentations

Bart Haynes presents on the future of HIV-1 vaccine development
XIX International AIDS Conference
July 25, 2012