Clive Gray, MSc, PhD


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Investigator in Clinical Sites Core and Immune Monitoring Core

Clive Gray, MSc, PhD is a Chief Specialist Scientist and Head of Department of HIV Immunology at the National Institute for Communicable Diseases, Johannesburg, South Africa. He received training as an Applied Biologist and specialized in immunology in 1984. His initial research was in transplantation immunology and understanding allo-recognition and innate immunity in solid organ transplantation. He was awarded a PhD in this field in 1994. Subsequently, he moved into HIV/AIDS research seeing this as a priority in the South African context. He was awarded the prestigious James Gear Fellowship in 1995, which allowed him to work at the Center for AIDS Research at Stanford University as a Post-doctoral Fellow. From 1996 to 1998, he was involved in investigating specific cellular immunity to HIV in individuals receiving antiretroviral drug therapy.

He was one of the first to publish on the restorative effects of HAART on the immune system and to describe the plasticity of the immune response. He subsequently showed that lymph node architecture also returns after effective drug therapy and suppression of HIV replication. He was also involved in the application of MHC tetramers whilst at Stanford, and was lead author on one of the first papers to show diminished antigen-specific CD8+ T cells in response to lowering antigen load by suppressing viral replication with HAART. He was responsible for co-coordinating one of the first workshops on HIV vaccines in Cape Town in early 1997 with the aim of initiating HIV vaccine research in South Africa. Since this time, he has been actively involved in the scientific agenda of vaccine development in South Africa and directs much of his energies to accomplishing this task. Currently he directs a SAAVI and HIV Vaccine Trials Network (HVTN) southern African Central Immunology Laboratory at the NICD for monitoring the immunogenicity of HIV-1 vaccines and understanding T cell immunity in HIV-1 infected individuals.

In 2004 he was the recipient of the Elizabeth Glaser AIDS Pediatric Foundation International Leadership Award. This was a three-year grant to fund Immunopaedia (, which uses a case study-centered approach to immunology learning and to understand the impact of HIV and other infectious diseases on the pediatric immune system.

He holds a Faculty positions as an Adjunct Professor in the Department of Immunology, Duke University, North Carolina, USA and at the Institute of Infectious Diseases and Molecular Medicine, University of Cape Town.